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簡(jiǎn)要描述：Nitroxoline 4008-48-4Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
產(chǎn)品型號(hào)：abs47027047廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-11-18訪 問 量：1046產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 4008-48-4 |
|---|---|---|---|
| 分子式 | C9H6N2O3 | 純度 | ＞98% |
| 分子量 | 190.16 | 貨號(hào) | abs47027047 |
| 規(guī)格 | 20mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a fluorquinolone that is active agai | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Nitroxoline 4008-48-4
| 產(chǎn)品描述 | |
| 描述 | Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 硝羥喹啉；5-硝基-8-羥基喹啉；8-Hydroxy-5-nitroquinoline；5-Nitro-8-quinolinol |
| 外觀 | 桔黃色至褐黃色結(jié)晶粉末 |
| 可溶性/溶解性 | DMSO : 36 mg/mL (189.3 mM) |
| 生物活性 | |
| 靶點(diǎn) | cathepsin B |
| In vitro(體外研究) | Nitroxoline significantly reduces extracellular DQ-collagen IV degradation by all evaluated cancer cell lines using spectrofluorimetry. Nitroxoline also markedly decreases tumor cell invasion monitored in real time and reduces the invasive growth of multicellular tumor spheroids, used as a 3D in vitromodel of tumor invasion. Endothelial tube formation is significantly reduced by nitroxoline in an in vitro angiogenesis assay. |
| In vivo(體內(nèi)研究) | Nitroxoline significantly abrogates tumor growth, angiogenesis and metastasis in vivo in LPB fibrosarcoma and MMTV-PyMT breast cancer mouse models. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer Metabolism CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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