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簡(jiǎn)要描述：Cetrimonium bromide 57-09-0儲(chǔ)存/保存方法Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
產(chǎn)品型號(hào)：abs47027095廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-11-25訪 問 量：1002產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 57-09-0 |
|---|---|---|---|
| 分子式 | C19H42BrN | 純度 | ＞98% |
| 分子量 | 364.46 | 貨號(hào) | abs4702709 |
| 規(guī)格 | 50mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a known component of the broad-spectr | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Cetrimonium bromide 57-09-0
| 產(chǎn)品描述 | |
| 描述 | Cetrimonium Bromide is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 西曲溴銨；十六烷基三甲基溴hua銨；Cetyltrimethylammonium Bromide； Hexadecyltrimethylammonium bromide； CTAB |
| 外觀 | 白色粉末 |
| 可溶性/溶解性 | DMSO : 5 mg/mL (13.71 mM) Ethanol : 93 mg/mL (255.2 mM) Water : 92 mg/mL (252.4 mM) |
| 生物活性 | |
| In vitro(體外研究) | Cetrimonium Bromide reduces cell viability of FaDu, C666-1, UTSCC-8A, UTSCC-42A, MRC5 cells and GM05757 fibroblasts with EC50 of 2 μM, 3.8 μM, 3.5 μM, 4.2 μM, 11 μM and 18 μM, respectively. Cetrimonium Bromide reduces cell viability of A549 lung and MCF7 breast cancer cells with EC50 of 17 μM and 12 μM. Cetrimonium Bromide (0.5 μM) interacts additively with radiation in a dose-dependent manner to exhibits inhibition effect on the clonogenic survival of FaDu cells. Cetrimonium Bromide results in nuclear condensation and blebbing in FaDu cells, consistent with apoptotic nuclear morphology, which is not observed in CTAB-treated GM05757 fibroblasts. Cetrimonium Bromide reproducibly decreases ATPase activity in a dose-dependent manner in FaDu cells, achieving ～90% inhibition at 50 μM. Cetrimonium Bromide (5 μM) causes a modest (～10%), but statistically significant decreases in ATP content in FaDu cells. Cetrimonium Bromide (5 μM) induced apoptosis is significantly suppressed by >50% when CCCP (5 μM) is used to effectively uncouple ΔΨM before Cetrimonium Bromide treatment in FaDu cells. |
| In vivo(體內(nèi)研究) | Cetrimonium Bromide (5 μM) effectively eliminates the tumor-forming potential of FaDu cells in SCID mice. Cetrimonium Bromide (daily 5 mg/kg i.p. for 5 days) induces a modest reduction in tumor development compared with the vehicle-treatment arm in established FaDu xenograft tumors in SCID mice. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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