Nicotinamide-N-oxide 1986-81-8

簡要描述：Nicotinamide-N-oxide 1986-81-8
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals.

產(chǎn)品型號：abs47027193
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-12-01
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品牌	absin	CAS	1986-81-8
分子式	C6H6N2O2	純度	＞99%
分子量	138.12	貨號	abs47027193
規(guī)格	50mg	供貨周期	現(xiàn)貨
主要用途	is recognized as an in vivo metabolite o	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Nicotinamide-N-oxide 1986-81-8

產(chǎn)品描述
描述	Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
純度	＞99%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	N-氧代yan酰胺；煙堿-N-氧化物
外觀	白色粉末
可溶性/溶解性	Limited solubility
生物活性
靶點	Drug Metabolite
In vitro(體外研究)	Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC50=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC50=110 nM) and potent inhibitor of neutrophil chemotaxis (IC50=170 nM).
參考文獻(xiàn)
參考文獻(xiàn)	1. Tian YJ, et al. Br J Nutr. 2014 May;111(9):1594-601. 2. Maeta A, et al. Biosci Biotechnol Biochem. 2014;78(8):1306-9. 3. Li D, et al. Br J Nutr. 2013 Dec; 110(12):2156-64.

研究領(lǐng)域
研究領(lǐng)域	Cell CycleCell Division Signal TransductionSignaling PathwayG Protein SignalingGPCR MicrobiologyOrganismVirusRNA VirusssRNA positive strand virusSARS Coronavirus Drug DiscoverySmall Molecule DrugLead Compound Discovery

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Nicotinamide-N-oxide 1986-81-8

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