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18438616290
簡要描述：Pregnenolone 145-13-1A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues.
產(chǎn)品型號：abs47027341廠商性質(zhì)：生產(chǎn)廠家更新時間：2025-12-08訪 問 量：768產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 145-13-1 |
|---|---|---|---|
| 分子式 | C21H32O2 | 純度 | ＞98% |
| 分子量 | 316.48 | 貨號 | abs47027341 |
| 規(guī)格 | 50mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | found in steroid hormone-producing tissu | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Pregnenolone 145-13-1
| 產(chǎn)品描述 | |
| 描述 | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 孕烯醇酮；3β-Hydroxy-5-pregnen-20-one |
| 外觀 | White to off-white Powder |
| 可溶性/溶解性 | DMSO : 12.5 mg/mL (39.50 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | progestogen Receptor |
| In vitro(體外研究) | Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. |
| In vivo(體內(nèi)研究) | Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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