Prazosin hydrochloride 19237-84-4

簡要描述：Prazosin hydrochloride 19237-84-4
Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

產(chǎn)品型號：abs47027465
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-12-15
訪問量：686

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品牌	absin	CAS	19237-84-4
分子式	C19H22ClN5O4	純度	＞98%
分子量	419.86	貨號	abs47027465
規(guī)格	50mg	供貨周期	現(xiàn)貨
主要用途	used to treat high blood pressure	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Prazosin hydrochloride 19237-84-4

產(chǎn)品描述
描述	Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	yan酸哌唑嗪；Prazosin HCl
外觀	白色或類白色結(jié)晶性粉末
可溶性/溶解性	DMSO : 25 mM Ethanol : 5 mM
生物活性
靶點	alpha-adrenergic receptor
In vitro(體外研究)	Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels. Prazosin (0.1 nM) blocks the increases in perfusion pressure caused by electrical stimulation of the perimesenteric nerves but does not significantly reduce the vasomotor effect of exogenous noradrenaline.
In vivo(體內(nèi)研究)	Prazosin application leads to the expansion of the capillary system by modulation of the hemodynamic environment (flow rate, shear stress) in skeletal muscle. Prazosin induces angiogenesis in extensor digitorum longus (EDL) muscles of C57BL/6 mice but not eNOS-knockout mice. Prazosin (0.5-2.0 mg/kg) blocks Yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking in rats. Prazosin (0.2mg kg(-1) s.c.) causes an enhancement of a suppression of conditioned avoidance response in the presence of the dopamine D2 receptor antagonist raclopride (0.05-0.20 mg/kg s.c.) in rats. Prazosin administration alone (1 mg/kg, s.c.) only slightly reduces horizontal activity during an initial 10 min measurement period, although it consistently reduces rearing in freely moving rats. Prazosin effectively suppresses the locomotor stimulation caused by either dose of MK-801 throughout the whole observation period in freely moving rats.
參考文獻
參考文獻	1. Chang HK, et al. J Pharm Pharmacol. 2003 Jun;55(6):833-7. 2. Thomas D, et al. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):462-72. 3. Hayer-Zillgen M, et al. Br J Pharmacol. 2002 Jul;136(6):829-36. 4. Polli JW, et al. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. 5. Dohse M, et al. Drug Metab Dispos. 2010 Aug;38(8):1371-80.

研究領(lǐng)域
研究領(lǐng)域	Cardiovascular CancerTumor biomarkers NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery

Prazosin hydrochloride 19237-84-4溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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Prazosin hydrochloride 19237-84-4

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