Bacitracin 1405-87-4

60u/mg

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

桿jun肽; Albac；Ziba-RX

white to faintly beige powder

Water : 100 mg/mL (70.98 mM)

DMSO : 100 mg/mL (70.98 mM)

Bacitracin is a potent antibiotic against gram-positive cocci, staphlococci, streptococci, corynebacteria, Treponema pallidum, T. vincenti, Actinomyces israeli, anaerobic cocci, clostridia, neisseria, most gonococci and meingococci, but it is relatively ineffective against most other gram-negative bacteria. Archaebacteria is also sensitive to Bacitracin. Of this group, Methanobacterium arbophilicum, M. M.O.H., M. O.H.G. and M. formicium showed inhibition by Bacitracin while Methanospirilum and Methanosarcina are insensitive to the antibiotic. Bacitracin affects a number of biochemical processes in bacteria, including metal ion transport, peptidoglycan synthesis, membrane permeability, and biosynthesis of inducible enzymes. Many of the biological properties of Bacitracin can be attributed to its high affinity for polyisoprenyl pyrophosphates. Aside from the antibiotic activity of the Bacitracins, these peptides have proven useful as a tool for investigating lipid-protein interactions at the molecular level. Bacitracin is also a known inhibitor of insulin degradation by both isolated cells and subcellular organelles, which inhibits the ability of purified glutathione-insulin transhydrogenase to split insulin into its constituent A and B chains. At concentrations of 90 and 300μM, Bacitracin inhibits 50 and 90%, respectively, of the degrading activity of the purified enzyme. Similarly, degradation by crude liver lysates is inhibited 50 and 90% by 70 and 250 μM Bacitracin, respectively. Bacitracin decreases both the Vmax and affinity of the enzyme for insulin. Bacitracin is able to inhibit the reductive function of the plasma membrane by against protein disulfide-isomerase. Bacitracin is able to induce inhibition of the cleavage of a disulfide-linked iodotyramine/poly(D-lysine) conjugate which bounds nonspecifically to the surface of CHO cells. Bacitracin also inhibits the cytotoxicity of diphtheria toxin, adisulfide-linked heterodimer that binds to a specific surface receptor and must undergo chain separation to exert its cytotoxicity.