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18438616290
簡要描述：Levonorgestrel 797-63-7Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device.
產(chǎn)品型號(hào)：abs47027592廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-19訪 問 量：715產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 797-63-7 |
|---|---|---|---|
| 分子式 | C21H28O2 | 純度 | 99% |
| 分子量 | 312.45 | 貨號(hào) | abs47027592 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a Progestin and Progestin-containing | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Levonorgestrel 797-63-7
| 產(chǎn)品描述 | |
| 描述 | Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 左炔諾yun酮 |
| 外觀 | 白色或類白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 31.3 mg/mL (100 mM) |
| 生物活性 | |
| 靶點(diǎn) | Progesterone receptor |
| In vitro(體外研究) | Levonorgestrel suppresses the stimulation of progesterone secretion induced by oLH, dibutyryl-cAMP and Pregnenolone in rats luteal cells. Levonorgestrel also inhibits constrictions evoked by either a high potassium (K(+)) solution or phorbol myristate acetate (PMA) in the absence and presence of extracellular calcium (Ca(2+)). Levonorgestrel depresses contractions evoked by Ca(2+) and reduces (45)Ca(2+) influx in depolarized veins. Levonorgestrel increases levels of cyclic AMP and inhibits PMA-induced activation of protein kinase C in veins. Levonorgestrel causes endothelium-independent relaxations of jugular veins via inhibition of Ca(2+) entry and of protein kinase Cactivation. Levonorgestrel inhibition of both estrogen-induced pituitary weight increment and hyperprolactinemia is reduced by mifepristone, whereas Flutamide is unable to block Levonorgestrel effects |
| In vivo(體內(nèi)研究) | Levonorgestrel down-regulates the mRNA expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) β and progesterone receptor (PR) in the ovary, and ERα and PR in the uterus of Mongolian gerbils. Levonorgestrel causes a significant upregulation of the mRNA expression of the gene encoding luteinising hormone β-subunit (lhβ) and the suppression of the mRNA expression of the gene encoding follicle-stimulating hormone β-subunit (fshβ) in the pituitary of both male and female roach. Levonorgestrel disrupts the reproductive system of pubertalroach by affecting the pituitary gonadotropin expression and the sex steroid levels in pubertal roach (Rutilus rutilus). |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsProgesterone CancerTumor biomarkersReceptors EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsProgesterone EpigeneticsTranscriptionDomain FamiliesZinc Finger NeuroscienceDevelopment NeuroscienceProcesses NeuroscienceEndocrine systemGonadotrophic axis Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsProgesterone Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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