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簡(jiǎn)要描述：Fesoterodine fumarate 286930-03-8Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antag
產(chǎn)品型號(hào)：abs47027716廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-25訪 問 量：655產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 286930-03-8 |
|---|---|---|---|
| 分子式 | C26H37NO3.C4H4O4 | 純度 | ＞98% |
| 分子量 | 527.65 | 貨號(hào) | abs47027716 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an antimuscarinic agent | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Fesoterodine fumarate 286930-03-8
| 產(chǎn)品描述 | |
| 描述 | Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder |
| 基本信息 | |
| 別名 | 富馬酸非索羅定 |
| 外觀 | 白色至類白色固體 |
| 可溶性/溶解性 | DMSO : 93 mg/mL (176.3 mM) Ethanol : 93 mg/mL (176.3 mM) Water : 92 mg/mL (174.4 mM) |
| 生物活性 | |
| 靶點(diǎn) | AChR |
| In vitro(體外研究) | Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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