Vidarabine 5536-17-4

簡要描述：Vidarabine 5536-17-4
Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses.

產(chǎn)品型號：abs47027732
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-12-26
訪問量：589

產(chǎn)品咨詢聯(lián)系我們

產(chǎn)品分類

Product Category

生化試劑

其它生化試劑植物提取物碳水化合物生物緩沖劑熒光探針與染料表面活性劑酶&輔酶&酶底物蛋白質(zhì)組學動植物激素小分子化合物生化檢測試劑盒逆行示蹤劑抗生素核苷&核苷酸多肽

查看全部

詳細介紹

品牌	absin	CAS	5536-17-4
分子式	C10H13N5O4	純度	＞99%
分子量	267.24	貨號	abs47027732
規(guī)格	50mg	供貨周期	現(xiàn)貨
主要用途	is an antiviral drug	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Vidarabine 5536-17-4

產(chǎn)品描述
描述	Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses.
純度	＞99%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	阿糖腺苷；Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine
外觀	白色針狀結晶或結晶性粉末
可溶性/溶解性	DMSO : 49 mg/mL (183.4 mM) Water : 3 mg/mL (11.22 mM)
生物活性
靶點	HSV
In vitro(體外研究)	Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells.Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo.
In vivo(體內(nèi)研究)	Vidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite.
參考文獻
參考文獻	1. Suzuki M, et al. Antiviral Res. 2006 Nov; 72(2):157-61. 2. Henrot A. Ann Dermatol Venereol. 2002 Apr;129(4 Pt 2):533-49.

研究領域
研究領域	MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

Vidarabine 5536-17-4溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

產(chǎn)品咨詢

留言框

產(chǎn)品：
您的單位：
您的姓名：
聯(lián)系電話：
常用郵箱：
省份：
詳細地址：
補充說明：
驗證碼：

請輸入計算結果（填寫阿拉伯數(shù)字），如：三加四=7

上一篇：abs47027731Imipenem 74431-23-5
下一篇：abs47027733Cyclobenzaprine hydrochloride 6202-23-9

Vidarabine 5536-17-4

留言框

產(chǎn)品：

您的單位：

您的姓名：

聯(lián)系電話：

常用郵箱：

省份：

詳細地址：

補充說明：

驗證碼：