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簡要描述：Amitraz 33089-61-1Amitraz是一種非系統(tǒng)性殺螨劑和殺蟲劑, 具有α-腎上腺素能激動(dòng)劑活性, 與中樞神經(jīng)系統(tǒng)的章魚胺受體相互作用, 且抑制單胺氧化酶和前列腺素合成。
產(chǎn)品型號：abs47027793廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-30訪 問 量：744產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 33089-61-1 |
|---|---|---|---|
| 分子式 | C19H23N3 | 純度 | 99% |
| 分子量 | 293.41 | 貨號 | abs47027793 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | 是一種非系統(tǒng)性殺螨劑和殺蟲劑 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Amitraz 33089-61-1
| 產(chǎn)品描述 | |
| 描述 | Amitraz是一種非系統(tǒng)性殺螨劑和殺蟲劑, 具有α-腎上腺素能激動(dòng)劑活性, 與中樞神經(jīng)系統(tǒng)的章魚胺受體相互作用, 且抑制單胺氧化酶和前列腺素合成。 |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 雙甲脒；BTS-27419 |
| 外觀 | 白色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 50 mg/mL (170.41 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | α2 adrenergic receptor |
| In vitro(體外研究) | Amitraz was not cytotoxic to human luteinized granulosa cells at concentrations of 1, 10 or 50 µg/ml for exposures of 2-72 h While the highest concentration of amitraz tested, 100 µg/ml, caused significant cell death after exposures of 24, 48 and 72 h. Amitraz decreased the amount of progesterone produced by each cell after a 4 h exposure; the reduction in progesterone concentration was not caused by decreased cell viability. |
| In vivo(體內(nèi)研究) | Amitraz is an α2-adrenergic receptor (α2-AR) agonist that adversely affects the mammalian reproductive system by binding to presynaptic α2-AR in the hypothalamus, thus inhibiting noradrenalin release and decreasing GnRH secretion. When 30 mg/kg of amitraz was administered to rats, the ovulatory LH surge was prevented. Amitraz inhibited insulin but stimulated glucagon secretion in a perfused rat pancreas model. Amitraz also decreased intestinal motility, and inhibited prostaglandin synthesis by bovine seminal vesicle microsomes. Amitraz can be absorbed through the skin and can exert systemic effects via the vascular system in humans. Low doses of AMZ (l-25 mg/kg) decreased motor activity and altered the rates and patterns of responding under schedule-controlled conditions. Intermediate doses (50-100 mg/kg) affect visual-evoked potentials and lower body weight and temperature. In addition, 100 mg/kg produces slight MAO inhibition and characteristic signs of intoxication (e.g., weight loss and hyperreactivity). High doses (>lOO mg/kg) produce more pronounced MAO inhibition, extreme weight loss and hyperreactivity, aggression, and lethality. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | MetabolismTypes of disease NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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