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簡(jiǎn)要描述：Rosuvastatin 287714-41-4Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.
產(chǎn)品型號(hào)：abs47027815廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-31訪 問 量：774產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 287714-41-4 |
|---|---|---|---|
| 分子式 | C22H28FN3O6S | 純度 | 98% |
| 分子量 | 481.54 | 貨號(hào) | abs47027815 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an antilipemic agent | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Rosuvastatin 287714-41-4
| 產(chǎn)品描述 | |
| 描述 | Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 瑞shu伐他汀；羅伐他汀 ; ZD 4522 |
| 外觀 | White to light yellow powder |
| 可溶性/溶解性 | DMSO ：≥50mg/ml |
| 生物活性 | |
| 靶點(diǎn) | HMG-CoA reductase |
| In vitro(體外研究) | Rosuvastatin possesses a greater number of binding interactions with HMG-CoA reductase and has a high affinity for the active site of the enzyme. Rosuvastatin is relatively hydrophilic and is selectively taken up by, and active in, hepatic cells. Rosuvastatin has the longest terminal half-life of the statins and is only minimally metabolized by the cytochrome P450 (CYP 450) enzyme system with no significant involvement of the 3A4 enzyme. |
| In vivo(體內(nèi)研究) | Rosuvastatin attenuates arterial thrombosis and neointima formation, and it may stabilise vascular lesions developing after endothelial injury in mice. These effects are independent of systemic lipid lowering. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteins CardiovascularAtherosclerosisLipoprotein metabolism CardiovascularLipids / LipoproteinsLipid MetabolismCholesterol Metabolism MetabolismTypes of diseaseHeart disease MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismCholesterol Metabolism MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolism MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipoprotein metabolism Signal TransductionMetabolismLipid metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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