Micafungin sodium 208538-73-2

簡要描述：Micafungin sodium 208538-73-2
Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.

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品牌	absin	CAS	208538-73-2
分子式	C56H70N9NaO23S	純度	98%
分子量	1292.26	貨號	abs47027856
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	used as an antifungal drug.	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Micafungin sodium 208538-73-2

產(chǎn)品描述
描述	Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, used as an antifungal drug.
純度	98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	米卡芬凈鈉；FK 463 sodium
可溶性/溶解性	DMSO : ≥ 32 mg/mL (24.76 mM)
生物活性
靶點	Fungal
In vitro(體外研究)	Micafungin is an antifungal agent that does not inhibit bacteria. Although micafungin does not inhibit the bacteria directly, it does promote the survival of G. mellonella. Micafungin inhibits biofilm formation by impeding 1,3-β-D-glucan synthesis in Candida albicans.
In vivo(體內研究)	Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals.

研究領域
研究領域	CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery

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