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簡(jiǎn)要描述：P7C3 301353-96-8The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration.
產(chǎn)品型號(hào)：abs47027860廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-05訪 問(wèn) 量：584產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 301353-96-8 |
|---|---|---|---|
| 分子式 | C21H18Br2N2O | 純度 | 98% |
| 分子量 | 474.19 | 貨號(hào) | abs47027860 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | shown to block neuronal cell death | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
P7C3 301353-96-8
| 產(chǎn)品描述 | |
| 描述 | The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, before neuronal cell death occurs, in a rodent model of blast-mediated traumatic brain injury (TBI). This protective quality may be linked to the ability of P7C3 molecules to activate nicotinamide phosphoribosyltransferase, the rate-limiting enzyme in nicotinamide adenine dinucleotide salvage. |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol |
| 外觀 | white to off-white |
| 可溶性/溶解性 | DMSO : 88 mg/mL (185.6 mM) Ethanol : 16 mg/mL (33.7 mM) |
| 生物活性 | |
| 靶點(diǎn) | NAMPT |
| In vitro(體外研究) | In U2OS Cells, P7C3 protects cells from doxorubicin-mediated toxicity, and enhances the flux of nicotinamide through the NAMPT-mediated salvage pathway. |
| In vivo(體內(nèi)研究) | In mouse brain, P7C3 (40 mg/kg, p.o.) induces neurogenesis and enhances survival of newborn neurons. In npas3?/? mice, P7C3 (20 mg/kg/d, p.o.) increases the magnitude of neural precursor cell proliferation, and corrects morphological and electrophysiological deficits. In the Ts65Dn mouse model of Down Syndrome, P7C3 restores hippocampal neurogenesis though a significant increase in total Ki67+, DCX+, and surviving BrdU+ cells. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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