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簡(jiǎn)要描述：Bioymifi 1420071-30-2Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis
產(chǎn)品型號(hào)：abs47027888廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-06訪 問(wèn) 量：788產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1420071-30-2 |
|---|---|---|---|
| 分子式 | C22H12BrN3O4S | 純度 | 98% |
| 分子量 | 494.32 | 貨號(hào) | abs47027888 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | can act as a single agent to induce DR5 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Bioymifi 1420071-30-2
| 產(chǎn)品描述 | |
| 描述 | Bioymifi can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis |
| 純度 | 98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | DR5 Activator |
| 外觀 | orange to dark orange red powder |
| 可溶性/溶解性 | DMSO : 12.5 mg/mL (25.29 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | DR5 receptor |
| In vitro(體外研究) | Bioymifi is able to promote cell death without the need for the Smac mimetic in T98G cells. At a 10 μM concentration, bioymifi induces processing of caspase-3 into smaller fragments. Caspase-8 and the related extrinsic apoptotic pathway are essential for bioymifi-induced cell death. Bioymifi induces DR5-dependent death pathways and is independent of TRAIL. Bioymifi binds the ECD of DR5 with a Kd of 1.2 μM but shows little binding affinity to the DR4 ECD. It has poor solubility in buffer solutions. Bioymifi promotes apoptosis by directly binding to and facilitating aggregation of DR5. When bioymifi reaches micromolar concentration, its capability to aggregate DR5 is strong enough to induce apoptosis in various cancer cells. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerGrowth factorsTNF CardiovascularAtherosclerosisVascular InflammationInflammatory mediators ImmunologyInnate ImmunityCytokinesTNF Superfamily MetabolismTypes of diseaseMetabolic disorders MicrobiologyOrganismVirusDNA VirusssRNA positive strand virusSARS Coronavirus NeuroscienceDevelopment NeuroscienceDiseases NeuroscienceProcesses Signal TransductionGrowth Factors/HormonesTNF Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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