全國服務咨詢熱線：
18438616290
<b id="grzca"><menuitem id="grzca"></menuitem></b>
18438616290
簡要描述：Maribavir 176161-24-3Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97.
產品型號：abs47027923廠商性質：生產廠家更新時間：2026-01-07訪 問 量：670產品分類
Product Category詳細介紹
| 品牌 | absin | CAS | 176161-24-3 |
|---|---|---|---|
| 分子式 | C15H19Cl2N3O4 | 純度 | 98% |
| 分子量 | 376.235 | 貨號 | abs47027923 |
| 規(guī)格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is by inhibition of an HCMV encoded pro | 應用領域 | 化工,生物產業(yè),農林牧漁,制藥/生物制藥,綜合 |
Maribavir 176161-24-3
| 產品描述 | |
| 描述 | Maribavir(GW257406X; BW1263W94; 1263W94) inhibits HCMV replication is by inhibition of an HCMV encoded protein kinase enzyme called UL97 or pUL97. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 馬立巴韋; 1263W94；BW1263W94； GW257406X |
| 可溶性/溶解性 | DMSO : 200 mg/mL (531.58 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點 | CMV |
| In vitro(體外研究) | Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a Ki of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM. |
| 研究領域 | |
| 研究領域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產品咨詢
地址：上海市浦東新區(qū)新浩路58號申江科創(chuàng)園18棟
郵箱：
傳真：