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簡(jiǎn)要描述：Tacrine hydrochloride hydrate 206658-92-6Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively.
產(chǎn)品型號(hào)：abs47027938廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-08訪 問(wèn) 量：585產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 206658-92-6 |
|---|---|---|---|
| 分子式 | C13H14N2.HCl.XH2O | 純度 | ＞98% |
| 分子量 | 234.72 | 貨號(hào) | abs47027938 |
| 規(guī)格 | 50mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an inhibitor of both acetyl | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Tacrine hydrochloride hydrate 206658-92-6
| 產(chǎn)品描述 | |
| 描述 | Tacrine hydrochloride hydrate is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 他克林鹽酸鹽水合物 |
| 可溶性/溶解性 | DMSO : 32 mg/mL (126.61 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶點(diǎn) | AChE,BChE |
| In vitro(體外研究) | Tacrine hydrochloride hydrate (12.5 to 37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner. The IC50 is 31 nM for snake venom AChE and 25.6 nM for human BChE. |
| In vivo(體內(nèi)研究) | Pretreatment with Tacrine hydrochloride hydrate also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride hydrate. Delivery of Tacrine hydrochloride hydrate by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride hydrate treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to Tacrine hydrochloride hydrate- but not saline- treated rats evaluated by conditioned-place preference. |
| 參考文獻(xiàn) | |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CardiovascularHeartCardiac arrhythmias NeuroscienceProcesses NeuroscienceNeurotransmitterAcetylcholine Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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