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18438616290
簡(jiǎn)要描述：GHF-5074 749269-83-8CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
產(chǎn)品型號(hào)：abs47027967廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-09訪 問(wèn) 量：646產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 749269-83-8 |
|---|---|---|---|
| 分子式 | C16H11Cl2FO2 | 純度 | 99% |
| 分子量 | 325.162 | 貨號(hào) | abs47027967 |
| 規(guī)格 | 2mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a novel γ-secretase modulator | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
GHF-5074 749269-83-8
| 產(chǎn)品描述 | |
| 描述 | CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點(diǎn) | γ secretase |
| In vitro(體外研究) | In human neuroglioma cells over-expressing the Swedish mutated APP , CHF5074 preferentially lowers Aβ42 secretion with an IC50 of 3.6 µmol/L. CHF5074 does not display inhibitory activity on COX-1 and COX-2 enzymes when employed at concentrations up to 100 µmol/L and 300 µmol/L respectively. |
| In vivo(體內(nèi)研究) | In rats, CHF5074 is orally well absorbed (50%) and is slowly eliminated from plasma (t1/2 ≈ 20 h). In Tg2576 transgenic mice, chronic treatment with CHF5074 markedly reduces brain Aβ burden without histological signs of peripheral Notch-mediated toxicity. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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