Efonidipine 111011-63-3

簡要描述：Efonidipine 111011-63-3
Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).

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詳細介紹

品牌	absin	CAS	111011-63-3
分子式	C34H38N3O7P	純度	98%
分子量	631.66	貨號	abs47027996
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a dual T-type and L-type calcium chan	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Efonidipine 111011-63-3

產(chǎn)品描述
描述	Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
純度	98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	依福地平; NZ-105；(±)-Efonidipine
可溶性/溶解性	10 mM in DMSO
生物活性
靶點	T-type calcium channel
In vitro(體外研究)	Although efonidipine is not a specific T-type calcium channe (TTCC) blocker as it could also block L-type calcium channe (LTCC), its efficacy in blocking TTCC is much greater than that of LTCC. Efonidipine exerts an inhibitory effect on aldosterone synthesis and secretion in a human adrenocortical cell line (H295R), an effect that is mediated, at least in part, by suppression of 11-β-hydroxylase and aldosterone synthase expression. Efonidipine also suppresses both Ang II- and K+-induced aldosterone secretion, but it blocks the latter at much lower concentrations than the former.
In vivo(體內研究)	Efonidipine could provide broader beneficial effects including the heart, liver, and plasma, and antioxidant in iron-overload condition in both WT(muβ+?+) and HT(muβth-3 ?+,) mice.

研究領域
研究領域	Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery

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