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簡(jiǎn)要描述：Nedaplatin 95734-82-0Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent.
產(chǎn)品型號(hào)：abs47028039廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-14訪 問 量：721產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 95734-82-0 |
|---|---|---|---|
| 分子式 | C2H8N2O3Pt | 純度 | ＞98% |
| 分子量 | 303.18 | 貨號(hào) | abs47028039 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a derivative of cisplatin | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Nedaplatin 95734-82-0
| 產(chǎn)品描述 | |
| 描述 | Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 奈da鉑；順糖an鉑;NSC 375101D |
| 外觀 | 稻黃色粉末 |
| 可溶性/溶解性 | Water : 15 mg/mL (49.5 mM) |
| 生物活性 | |
| 靶點(diǎn) | DNA synthesis |
| In vitro(體外研究) | Nedaplatin (Aqupla) is a derivative of cisplatin for inhibition of tumor colony forming units with IC50 of 28.5 μg/mL. Nedaplatin is a platinum compound which is used for cancer chemotherapy. Nedaplatin inhibits the proliferation of SBC-3 cells by 98%, 93%, 75%, 54%, 27%, 6%, and 2% at a concentration of 0.005 μg/mL, 0.01 μg/mL, 0.025 μg/mL, 0.05 μg/mL, 0.1 μg/mL, 0.25 μg/mL, and 0.5 μg/mL, respectively. The IC50 value of Nedaplatin for growth inhibition of SBC-3 cells is 0.053 μg/mL. |
| In vivo(體內(nèi)研究) | The sequential administration of 5-FU prior to nedaplatin or CDDP (FN or FC therapy) results in synergistically enhanced inhibition of tumour growth and prolonged survival in comparison with nedaplatin, CDDP or 5-FU monotherapy. Combined dosing of Nedaplatin with gemcitabine results in synergistically enhanced inhibition of tumor growth in the Ma44 tumor model. Nedaplatin plus Gemcitabine is also effective against Ma44 cells when given late in the therapy, a model for advanced disease. Potent augmentation of growth inhibition by Nedaplatin with Gemcitabine is also found with the NCI-H460 tumor model. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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