CH 223191 301326-22-7

簡(jiǎn)要描述：CH 223191 301326-22-7
CH 223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.

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品牌	absin	CAS	301326-22-7
分子式	C19H19N5O	純度	＞98%
分子量	333.39	貨號(hào)	abs47028049
規(guī)格	5mg	供貨周期	現(xiàn)貨
主要用途	is a potent and specific aryl hydrocarbo	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

CH 223191 301326-22-7

產(chǎn)品描述
描述	CH 223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist with IC50 of 30 nM.
純度	＞98%
儲(chǔ)存/保存方法	Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	CH-223191；CH223191
外觀	Yellow to orange powder
可溶性/溶解性	Ethanol ：3.3 mg/mL (10 mM) DMSO ：33.3 mg/mL (100 mM)
生物活性
靶點(diǎn)	AhR
In vitro(體外研究)	CH-223191 blocks TCDD-mediated nuclear translocation and DNA binding of AhR, and also causes the inhibition of TCDD-induced cytochrome P450 enzyme activity. In human glioblastoma cells, CH-223191downregulates the TGF-beta/Smad pathway, and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH223191 counteracts the TCDD-induced suppression of neuronal acetylcholinesterase expression. In endothelial cells, CH-223191 potentiates ICAM-1 expression and prevents RelB nuclear translocation.
In vivo(體內(nèi)研究)	CH-223191 (10 mg/kg/day, p.o.) potently prevents TCDD-caused cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.

研究領(lǐng)域
研究領(lǐng)域	EpigeneticsTranscriptionDomain FamiliesHLH / Leucine ZipperHelix-Turn-Helix NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery

CH 223191 301326-22-7溫馨提示：本產(chǎn)品僅作科研實(shí)驗(yàn)使用，不支持臨床等研究

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