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18438616290
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18438616290
簡(jiǎn)要描述：CID755673 521937-07-5CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM
產(chǎn)品型號(hào)：abs47028051廠(chǎng)商性質(zhì)：生產(chǎn)廠(chǎng)家更新時(shí)間：2026-01-14訪(fǎng) 問(wèn) 量：658產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 521937-07-5 |
|---|---|---|---|
| 分子式 | C12H11NO3 | 純度 | ＞98% |
| 分子量 | 217.22 | 貨號(hào) | abs47028051 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent and selective cell-active sm | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
CID755673 521937-07-5
| 產(chǎn)品描述 | |
| 描述 | CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | CID 755673 |
| 外觀(guān) | Brown powder |
| 可溶性/溶解性 | DMSO : 21.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶點(diǎn) | PKD1 ,PKD3 ,PKD2 |
| In vitro(體外研究) | In LNCaP prostate cancer cells, CID755673 directly inhibits PKD1 activity. In HeLa cells, CID755673 significantly blocks PMA-induced nuclear export of HDAC5, and blocks PKD-mediated protein transport. In prostate cancer cells, CID755673 potently blocks cell migration and invasion, and also shows inhibition activity on tumor cell proliferation and cell cycle distribution. In addition, CID755673 alter primary human NK cell effector functions. |
| In vivo(體內(nèi)研究) | CID755673, via PKD/PKD1 inhibition, significantly ameliorates necrosis and severity of pancreatitis in a rat acute pancreatitis model. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteins MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolism NeuroscienceDevelopment Signal TransductionProtein PhosphorylationSer / Thr KinasesPKC Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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