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簡要描述：INH1 313553-47-8INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
產(chǎn)品型號：abs47028062廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-01-15訪 問 量：634產(chǎn)品分類
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| 品牌 | absin | CAS | 313553-47-8 |
|---|---|---|---|
| 分子式 | C18H16N2OS | 純度 | 99% |
| 分子量 | 308.4 | 貨號 | abs47028062 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a cell-permeable Hec1 inhibitor | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
INH1 313553-47-8
| 產(chǎn)品描述 | |
| 描述 | INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
| 純度 | 99% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 200 mM in DMSO and ethanol |
| 生物活性 | |
| 靶點 | Hec1 |
| In vitro(體外研究) | INH1 reduces the association of Hec1 with kinetochore and decreases global Nek2 protein level in cells. INH1 effectively inhibits the proliferation of human breast cancer lines with GI50 of 10-21 μM. Moreover, INH1 also elicits cell killing activity in part through impairing the Hec1/Nek2 pathway for the spindle checkpoint regulation. |
| In vivo(體內(nèi)研究) | INH1 (100 mg/kg i.p.) inhibits breast tumor growth in mice bearing MDA-MB-468 human breast cancer xenograft. |
| 參考文獻 | |
| 參考文獻 |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCell cycleCell division Cell CycleCell Division Cell CycleKinases/PhosphatasesOther Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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