Rufinamide 106308-44-5

簡要描述：Rufinamide 106308-44-5
Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.

產(chǎn)品型號：abs47028065
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2026-01-15
訪問量：587

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品牌	absin	CAS	106308-44-5
分子式	C10H8F2N4O	純度	＞98%
分子量	238.19	貨號	abs47028065
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	used an anticonvulsant medication	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Rufinamide 106308-44-5

產(chǎn)品描述
描述	Rufinamide is a voltage-gated sodium channel blocker, used an anticonvulsant medication.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	盧非酰胺；CGP 33101；E 2080；RUF 331
外觀	白色粉末
可溶性/溶解性	DMSO : 47 mg/mL (197.32 mM), warmed
生物活性
靶點	Sodium channel
In vitro(體外研究)	Rufinamide is extensively metabolised by non-CYP450 systems with a half-life of 8-12 hours. Rufinamide’s mechanism of action is thought to be inhibition of sodium-dependent action potentials in neurons, with possible membrane-stabilising effects. Rufinamide hydrolysis is mediated primarily by human carboxylesterase (hCE) 1 and is nonsaturable up to 500 μM.
In vivo(體內(nèi)研究)	Rufinamide given orally at 20 mg/kg every 12 h in healthy dogs should result in a plasma concentration and half-life sufficient to achieve the therapeutic level extrapolated from humans without short-term adverse effects in adult dogs. Rufinamide alleviates injury-induced mechanical allodynia for 4 hours. Rufinamide reduces peak current and stabilizes the inactivated state of voltage-gated sodium channel Nav1.7, with similar effects in dorsal root ganglion neurons in the Spared Nerve Injury neuropathic pain model in mice. Rufinamide suppresses pentylenetetrazol-induced seizures in mice (ED(50) 45.8 mg/kg) but not rats, and is active against MES-induced tonic seizures in mice (ED(50) 23.9 mg/kg) and rats (ED(50) 6.1 mg/kg). Rufinamide suppresses pentylenetetrazol-, bicuculline-, and picrotoxin-induced clonus in mice (ED(50) 54.0, 50.5, and 76.3 mg/kg, respectively). Rufinamide is partially effective in the mouse strychnine test.
參考文獻(xiàn)
參考文獻(xiàn)	1. Wright HM, et al. J Vet Pharmacol Ther,?012, 35(6), 529-533. 2. Suter MR, et al. Anesthesiology,?013, 118(1), 160-172.

研究領(lǐng)域
研究領(lǐng)域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Rufinamide 106308-44-5溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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Rufinamide 106308-44-5

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