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18438616290
簡要描述：SNS-314 Mesylate 1146618-41-8SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively.
產(chǎn)品型號：abs47028109廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-01-19訪 問 量：589產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1146618-41-8 |
|---|---|---|---|
| 分子式 | C18H15ClN6OS2.CH4O3S | 純度 | 98% |
| 分子量 | 527.04 | 貨號 | abs47028109 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent and selective inhibitor of A | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
SNS-314 Mesylate 1146618-41-8
| 產(chǎn)品描述 | |
| 描述 | SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO : 50 mg/mL (94.87 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點 | Aurora C,Aurora A,Aurora B |
| In vitro(體外研究) | In HCT116 colorectal carcinoma cell line, with intact or depleted p53 protein levels, SNS-314 Mesylate shows enhanced efficacy when administered sequentially with other standard chemotherapeutic agents and the most profound synergies are identified for agents that activate the spindle assembly checkpoint, e.g., docetaxel and vincristine. A recent study shows that SNS-314 Mesylate shows potent antiproliferative activity in HCT116 cells and inhibits soft agar colony formation. |
| In vivo(體內(nèi)研究) | The sequential treatment with SNS-314 Mesylate followed by docetaxel 24 hours later produces a significant 72.5% tumor growth inhibition of HCT116 xenografts, while docetaxel and SNS-314 Mesylate as single agents produce no significant inhibition of HCT116 tumor growth. In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 Mesylate results a dose-dependent inhibition of histone H3 phosphorylation, indicating effective Aurora-B inhibition in vivo. In addition, HCT116 tumors from animals treated with SNS-314 Mesylate exhibits potent and sustained responses including reduction of phosphorylated histone H3 levels, increased caspase-3 and appearance of increased nuclear size. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCell cycleCell division CancerTumor biomarkersOther Cell CycleCell DivisionSpindle Signal TransductionProtein PhosphorylationSer / Thr KinasesAurora Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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