A-1210477 1668553-26-1

簡要描述：A-1210477 1668553-26-1
A-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.

產(chǎn)品型號：abs47028115
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2026-01-19
訪問量：667

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品牌	absin	CAS	1668553-26-1
分子式	C46H55N7O7S	純度	99%
分子量	850.04	貨號	abs47028115
規(guī)格	5mg	供貨周期	現(xiàn)貨
主要用途	is a potent and selective MCL-1	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

A-1210477 1668553-26-1

產(chǎn)品描述
描述	A-1210477 is a potent and selective MCL-1 and Bcl-2 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.
純度	99%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	10 mM in DMSO
生物活性
靶點	MCL-1
In vitro(體外研究)	In H929 cells, A-1210477 binds to MCL-1 with high affinity and induces MCL-1 protein elevation. In H929, H2110, and H23 cells, A-1210477 induce the hallmarks of apoptosis, and inhibits MCL-1-dependent cell viability. A-1210477 also synergizes with navitoclax to kill a variety of cancer cell lines. In SKBR3 cells, A-1210477 inhibits MCL-1–BIM interaction and induces classical features of apoptosis. In addition, A-1210477 sensitizes non-Hodgkin's lymphoma cell lines to venetoclax (ABT-199).
參考文獻(xiàn)
參考文獻(xiàn)	1. Bruncko M, et al. J Med Chem. 2015 Mar 12;58(5):2180-2194. 2. Leverson JD, et al. Cell Death Dis. 2015 Jan 15;6:e1590.

研究領(lǐng)域

CancerCancer MetabolismCellular metabolic process

CancerCancer MetabolismResponse to hypoxia

CancerCell DeathApoptosisMetabolism

CancerCell DeathApoptosisApoptosis MarkersBcl 2 family

CancerInvasion/microenvironmentApoptosisBcl 2 family

CancerOncoproteins/suppressorsOncoproteinsCell survival & death

CancerTumor biomarkersOncoproteins

ApoptosisIntracellularBcl2 Family

MetabolismTypes of diseaseCancer

MetabolismPathways and ProcessesMetabolism processesApoptosis

MetabolismPathways and ProcessesMetabolism processesHypoxia

MetabolismPathways and ProcessesMitochondrial MetabolismMitochondrial markers

Signal TransductionMetabolismMitochondrial

Drug DiscoverySmall Molecule DrugLead Compound Discovery

A-1210477 1668553-26-1溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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A-1210477 1668553-26-1

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