全國(guó)服務(wù)咨詢熱線：
18438616290
<b id="grzca"><menuitem id="grzca"></menuitem></b>
18438616290
簡(jiǎn)要描述：Fruquintinib 1194506-26-7Fruquintinib (HMPL-013) is a small molecule vascular endothelial growth factor receptors inhibitor.
產(chǎn)品型號(hào)：abs47028123廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-19訪 問 量：587產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1194506-26-7 |
|---|---|---|---|
| 分子式 | C21H19N3O5 | 純度 | 99% |
| 分子量 | 393.39 | 貨號(hào) | abs47028123 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a small molecule vascular endothelial | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Fruquintinib 1194506-26-7
| 產(chǎn)品描述 | |
| 描述 | Fruquintinib (HMPL-013) is a small molecule vascular endothelial growth factor receptors inhibitor. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外觀 | white powder |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| 靶點(diǎn) | VEGFR3 ,VEGFR1 ,VEGFR2 |
| In vitro(體外研究) | In in vitro enzymatic and cellular assays, Fruquintinib inhibits VEGFR family kinases and suppressed VEGF/VEGFR cell signaling in human umbilical vein endothelial cell (HUVEC) and human lymphatic endothial cell (HLEC) with IC50 at low nanomolar level. Few kinases are inhibited other than VEGFRs in a panel of 253 kinases test. Fruquintinib is a highly potent inhibitor of VEGF-induced angiogenesis. |
| In vivo(體內(nèi)研究) | Fruquintinib demonstrates favorable pharmacokinetic profile in multiple animal species, oral administration of fruquintinib strongly suppressed VEGF-induced VEGFR2 phosphorylation in the lung tissue in mice. The extent and duration of the inhibition of VEGFR2 phosphorylation correlated well with drug exposures. The strong anti-angiogenic effect resulted in robust anti-tumor efficacy in a number of human tumor xenograft models with good dose response. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCancer MetabolismResponse to hypoxia CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors CardiovascularAngiogenesisEndothelial Cell Markers CardiovascularCardiovascular MarkersCell MarkersEndothelial Cells MetabolismTypes of diseaseCancer MetabolismPathways and ProcessesMetabolism processesHypoxia MicrobiologyInterspecies InteractionHost Virus Interaction NeuroscienceDevelopment NeuroscienceProcesses Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Stem CellsEndothelial ProgenitorsEndothelial Markers Stem CellsHematopoietic ProgenitorsSurface Molecules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
產(chǎn)品咨詢
地址：上海市浦東新區(qū)新浩路58號(hào)申江科創(chuàng)園18棟
郵箱：
傳真：