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18438616290
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ANA-12 219766-25-3 ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.
TAK875 1000413-72-8 TAK-875 is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, 400-fold more potent than oleic acid.
GSK2334470 1227911-45-6 GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.
BLU9931 1538604-68-0 BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50 150 nM).
LY344864 186544-26-3 LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
AS601245 345987-15-7 AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK) (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM), has neuroprotective properties.
SU-5614 1055412-47-9 SU-5614 is a potent and selective FLT3 inhibitor.
Vitamin K2 11032-49-8 Vitamin K2 may act by modulating the signalling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos.
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