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簡(jiǎn)要描述：Levamisole hydrochloride 16595-80-5Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders
產(chǎn)品型號(hào)：abs47027405廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-11訪 問 量：767產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 16595-80-5 |
|---|---|---|---|
| 分子式 | C11H12N2S.HCl | 純度 | 99% |
| 分子量 | 240.75 | 貨號(hào) | abs47027405 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an antihelminthic drug | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Levamisole hydrochloride 16595-80-5
| 產(chǎn)品描述 | |
| 描述 | Levamisole hydrochloride is an antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | yan酸左旋咪唑; (-)-Tetramisole hydrochloride |
| 外觀 | White to almost white Crystalline Powder |
| 可溶性/溶解性 | Water : 48 mg/mL (199.37 mM) DMSO : 15.5 mg/mL (64.38 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶點(diǎn) | nAChR,PLAP |
| In vitro(體外研究) | L-tetramisole (250 and 500 mg/mL) suppresses IFN synthesis in the cells from BALB/c and NZB mice. L-tetramisole (125 mg/mL) inhibits the IFN production only partially and this effect is observed when the IFN production is high. L-tetramisole affects the production of the physiological IFN, but not the production of IFN induced by Newcastle disease virus (NDV) in the peritoneal cells of mice or in L929 cells. |
| In vivo(體內(nèi)研究) | Tetramisole leads to the mean faecal egg count rose from 3 weeks after treatment and remain continuously higher than those Closantel or Albendazole treated group up to 12 weeks after treatment. Tetramisole reduces neuronal response amplitude in a dose-dependent manner in mouse cortex. Tetramisole also decreases axonal conduction velocity in mouse cortex. Tetramisole significantly increases the stereotyped behavior (grooming, sniffing, biting and licking and head bobbing) of the mice when compared to the control group. Tetramisole significantly increases stereotyped behavior of the mice on days 3, 5 and 8 in comparison with respective control values. Tetramisole treatments (0.5 and 1mg/kg) also significantly decreases the time needed to complete the negative geotaxis task and reduces landing foot splay. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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