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簡要描述：Corticosterone 50-22-6Corticosterone is a sensitive inhibitor of monoamine transport.
產(chǎn)品型號：abs47027406廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-11訪 問 量：792產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 50-22-6 |
|---|---|---|---|
| 分子式 | C21H30O4 | 純度 | ＞98% |
| 分子量 | 346.46 | 貨號 | abs47027406 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a sensitive inhibitor of monoamine t | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Corticosterone 50-22-6
| 產(chǎn)品描述 | |
| 描述 | Corticosterone is a sensitive inhibitor of monoamine transport. |
| 純度 | ＞98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 腎上腺酮；皮質(zhì)酮；17-Deoxycortisol； 11β,21-Dihydroxyprogesterone；Kendall's compound B |
| 外觀 | 白色或類白色粉末 |
| 可溶性/溶解性 | DMSO : 34.7 mg/mL (100 mM) Ethanol : 3.5 mg/mL (10 mM) |
| 生物活性 | |
| 靶點(diǎn) | Glucocorticoid receptor |
| In vitro(體外研究) | Corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane. It enhances AMPAR-mediated miniature excitatory postsynaptic current (mEPSC) amplitude and surface expression of GluR1 and GluR2 subunits in hippocampal neurons, increases the surface mobility and synaptic content of AMPAR GluR2 subunits, and enhances L-type calcium currents in CA1 pyramidal neurons. Corticosterone operates through mineralocorticoid receptors and glucocorticoid receptors, both of which belong to the family of nuclear receptors that bind to response elements in the DNA, thus modifying the activity of responsive genes. |
| In vivo(體內(nèi)研究) | Corticosterone plays an important role in regulating neuronal functions of the limbic system. After stress, the level of stress hormones such as corticosterone is markedly increased. Corticosterone exerts a time- and region-specific action on cellular physiology of limbic neurons. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerSignal transductionNuclear signalingNuclear hormone receptorsOther EpigeneticsNuclear Signaling PathwaysNuclear ReceptorsCorticoid NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNuclear Hormone ReceptorsCorticoid Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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