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簡(jiǎn)要描述：Floxuridine 50-91-9Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.
產(chǎn)品型號(hào)：abs47027416廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-11訪 問 量：720產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 50-91-9 |
|---|---|---|---|
| 分子式 | C9H11FN2O5 | 純度 | 99% |
| 分子量 | 246.19 | 貨號(hào) | abs47027416 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an oncology drug that belongs to the | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Floxuridine 50-91-9
| 產(chǎn)品描述 | |
| 描述 | Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 5-氟-2'-脫氧脲核苷；氟尿苷;5-Fluoro-2'-deoxyuridine |
| 外觀 | White to almost white Powder |
| 可溶性/溶解性 | DMSO : 125 mg/mL (507.74 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (203.10 mM) |
| 生物活性 | |
| 靶點(diǎn) | DNA/RNA Synthesis |
| In vitro(體外研究) | Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both -inosine and -adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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