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18438616290
簡(jiǎn)要描述：Albendazole 54965-21-8Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
產(chǎn)品型號(hào)：abs47027524廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-12-17訪 問 量：666產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 54965-21-8 |
|---|---|---|---|
| 分子式 | C12H15N3O2S | 純度 | 99% |
| 分子量 | 265.33 | 貨號(hào) | abs47027524 |
| 規(guī)格 | 25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | used as a drug | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
Albendazole 54965-21-8
| 產(chǎn)品描述 | |
| 描述 | Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. |
| 純度 | 99% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 阿苯da唑 |
| 外觀 | 白色至淡黃色結(jié)晶性粉末 |
| 可溶性/溶解性 | DMSO : 14 mg/mL (52.8 mM) |
| 生物活性 | |
| 靶點(diǎn) | tubulin |
| In vitro(體外研究) | Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. |
| In vivo(體內(nèi)研究) | Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | NeuroscienceCell Type MarkerNeuron markerAxon marker Signal TransductionCytoskeleton / ECMCytoskeletonMicrotubulesTubulin Tags & Cell MarkersSubcellular MarkersCytoskeletonMicrotubules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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