Mebendazole 31431-39-7

簡要描述：Mebendazole 31431-39-7
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations

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品牌	absin	CAS	31431-39-7
分子式	C16H13N3O3	純度	＞98%
分子量	295.3	貨號	abs47027525
規(guī)格	25mg	供貨周期	現(xiàn)貨
主要用途	is a highly effective	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Mebendazole 31431-39-7

產(chǎn)品描述
描述	Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	jia苯咪唑
外觀	白色至淡黃色結晶性粉末
可溶性/溶解性	DMSO : ≥ 23 mg/mL (77.89 mM)
生物活性
靶點	Parasite
In vitro(體外研究)	mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis.MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells.
In vivo(體內(nèi)研究)	When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis.MZ treatment significantly reduces vessel densities in mice compared with those in control mice.
參考文獻
參考文獻	1. Lubega GW, et al. Mol Biochem Parasitol. 1993 Dec;62(2):281-92. 2. MacDonald LM, et al. Mol Biochem Parasitol. 2004 Nov; 138(1):89-96. 3. Oxberry ME, et al. Parasitology. 2001 Jun; 122(Pt 6):683-7.

研究領域
研究領域	Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery

Mebendazole 31431-39-7溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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