Doxepin Hydrochloride 1229-29-4

簡(jiǎn)要描述：Doxepin Hydrochloride 1229-29-4
Doxepin Hydrochloride is a dibenzoxepin tricyclic compound.

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品牌	absin	CAS	1229-29-4
分子式	C19H22ClNO	純度	99%
分子量	315.84	貨號(hào)	abs47027747
規(guī)格	1g	供貨周期	現(xiàn)貨
主要用途	is a dibenzoxepin tricyclic compound	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Doxepin Hydrochloride 1229-29-4

產(chǎn)品描述
描述	Doxepin Hydrochloride is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
純度	99%
儲(chǔ)存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	鹽酸duo塞平
外觀	白色粉末
可溶性/溶解性	DMSO : ≥ 100 mg/mL (316.62 mM) H2O : ≥ 50 mg/mL (158.31 mM)
生物活性
靶點(diǎn)	Serotonin Transporter
In vitro(體外研究)	Doxepin inhibits the reuptake of serotonin and norepinephrine. Its actions of the reuptake of dopamine are negligible. Doxepin also has antagonistic effects at a variety of receptors including receptors of H1, H2, 5-HT1, 5-HT2, α1-adrenergic and mACh.
參考文獻(xiàn)
參考文獻(xiàn)	1. Ehlert FJ, et al. J Pharmacol Exp Ther. 1990 Apr;253(1):13-9. 2. Tatsumi M, et al. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. 3. Figueiredo A, et al. Fundam Clin Pharmacol. 1990;4(2):147-58. 4. Stahl SM, et al. CNS Spectr. 2008 Dec;13(12):1027-38. 5. Cusack B, et al. Psychopharmacology (Berl). 1994 May;114(4):559-65.

研究領(lǐng)域
研究領(lǐng)域	CancerCancer Metabolism CancerTumor immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery

Doxepin Hydrochloride 1229-29-4溫馨提示：本產(chǎn)品僅作科研實(shí)驗(yàn)使用，不支持臨床等研究

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