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18438616290
簡(jiǎn)要描述：SBE13 Hydrochloride 1052532-15-6SBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3.
產(chǎn)品型號(hào)：abs47027970廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-09訪 問(wèn) 量：592產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1052532-15-6 |
|---|---|---|---|
| 分子式 | C24H28Cl2N2O4 | 純度 | ≥98% |
| 分子量 | 479.40 | 貨號(hào) | abs47027970 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is a potent and selective PLK1 with IC50 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
SBE13 Hydrochloride 1052532-15-6
| 產(chǎn)品描述 | |
| 描述 | SBE13 hydrochloride is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3. |
| 純度 | ≥98% |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | SBE-13 HCl |
| 外觀 | white to tan powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (208.59 mM) H2O : 5 mg/mL (10.43 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點(diǎn) | PLK1 |
| In vitro(體外研究) | SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCell cycleCell division Cell CycleCell DivisionSpindle Cell CycleKinases/PhosphatasesOther EpigeneticsCell cycleKinases/PhosphatasesOther NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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