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18438616290
簡要描述：ITD-1 1099644-42-4ITD-1 is an inducer of TGF_beta_ type II receptor degradation-1, is a potent and highly selective TGF_beta_ pathway inhibitor (IC50 = 0.85 uM).
產(chǎn)品型號：abs47027971廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2026-01-09訪 問 量：588產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1099644-42-4 |
|---|---|---|---|
| 分子式 | C27H29NO3 | 純度 | ＞98% |
| 分子量 | 415.52 | 貨號 | abs47027971 |
| 規(guī)格 | 10mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is an inducer of TGF_beta_ type II rece | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
ITD-1 1099644-42-4
| 產(chǎn)品描述 | |
| 描述 | ITD-1 is an inducer of TGF_beta_ type II receptor degradation-1, is a potent and highly selective TGF_beta_ pathway inhibitor (IC50 = 0.85 uM). |
| 純度 | ＞98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | ITD 1 |
| 外觀 | Light yellow solid |
| 可溶性/溶解性 | DMSO : 28 mg/mL (67.39 mM) |
| 生物活性 | |
| 靶點(diǎn) | TGF-(beta) Receptor |
| In vitro(體外研究) | ITD-1 potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. HEK293T cells are transfected with a Smad4 response element driving luciferase (SBE4-Luc) to test whether ITD-1 blocks Activin A/Nodal and/or TGFβ signaling, which utilize the same intracellular signaling cascade through Smad4. ITD-1 strongly inhibits TGFβ2 signaling with similar efficacy (92% vs. 99% respectively), but with lower potency compared to SB-431542, an ACVR1B/TGFBR1 kinase inhibitor (IC50= 850nM vs. 70nM respectively), and is a weak and partial inhibitor of Activin A signals. ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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