Etravirine 269055-15-4

簡要描述：Etravirine 269055-15-4
Etravirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.

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品牌	absin	CAS	269055-15-4
分子式	C20H15BrN6O	純度	＞98%
分子量	435.28	貨號	abs47028080
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a diarylpyrimidine non-nucleoside rev	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Etravirine 269055-15-4

產(chǎn)品描述
描述	Etravirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	依曲韋林；R165335；TMC125
外觀	white to off-white
可溶性/溶解性	DMSO : 39 mg/mL (89.6 mM)
生物活性
靶點	Reverse transcriptase
In vitro(體外研究)	Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus.
In vivo(體內(nèi)研究)	Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.

研究領(lǐng)域
研究領(lǐng)域	MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery

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