Succimer 304-55-2

簡(jiǎn)要描述：Succimer 304-55-2
Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

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品牌	absin	CAS	304-55-2
分子式	C4H6O4S2	純度	＞98%
分子量	182.22	貨號(hào)	abs47028081
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a Lead Chelator.	應(yīng)用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Succimer 304-55-2

產(chǎn)品描述
描述	Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.
純度	＞98%
儲(chǔ)存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	二巰基丁二酸；Dimercaptosuccinic acid; DMSA
外觀	白色結(jié)晶性粉末
可溶性/溶解性	DMSO ：36 mg/mL (197.56 mM) Ethanol：3 mg/mL (16.46 mM)
生物活性
In vivo(體內(nèi)研究)	Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
參考文獻(xiàn)
參考文獻(xiàn)	1. Blanusa M, et al. Curr Med Chem. 2005;12(23):2771-94. 2. Aposhian HV, et al. Toxicology. 1995 Mar 31;97(1-3):23-38.

研究領(lǐng)域
研究領(lǐng)域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Succimer 304-55-2溫馨提示：本產(chǎn)品僅作科研實(shí)驗(yàn)使用，不支持臨床等研究

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