GSK 650394 890842-28-1

簡要描述：GSK 650394 890842-28-1
GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.

產(chǎn)品型號：abs47028111
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2026-01-19
訪問量：667

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品牌	absin	CAS	890842-28-1
分子式	C25H22N2O2	純度	＞98%
分子量	382.45	貨號	abs47028111
規(guī)格	10mg	供貨周期	現(xiàn)貨
主要用途	is a serum- and glucocorticoid-regulated	應用領(lǐng)域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

GSK 650394 890842-28-1

產(chǎn)品描述
描述	GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively.
純度	＞98%
儲存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
別名	GSK-650394；GSK650394
外觀	white to beige powder
可溶性/溶解性	DMSO : ≥ 40.7 mg/mL (106.42 mM)
生物活性
靶點	SGK1；SGK2
In vitro(體外研究)	GSK650394 inhibits SGK1-mediated epithelial transport with an IC50 of 0.6 μM in the SCC assay. In LNCaP cells, GSK650394 inhibits the androgen-mediated enhancement of Nedd4-2 phosphorylation and androgen-mediated cell growth. GSK650394 counteracts the Cortisol-induced decrease in neurogenesis, changes in Hedgehog signaling, and GR nuclear translocation. GSK 650394 inhibits replication of influenza virus by impairing the export of influenza vRNPs into the cytoplasm of A549 cells.
In vivo(體內(nèi)研究)	GSK650394 (1, 10, and 30 μM, 10 μL/rat, intrathecally) dose-dependently prevents CFA-induced pain behavior and the associates SGK1 phosphorylation, GluR1 trafficking, and protein-protein interactions at 1 day after CFA administration. GSK650394 at concentrations of 10, 30, and 100 nM (10 μL), but not vehicle solution (SNL 3D+Veh and SNL 7D+Veh, respectively), dose-dependently increases the withdrawal latency of the ipsilateral hindpaw at 1-3 and 1-5 h after injection at days 3 and 7 postsurgery (SNL 3D+GSK and SNL 7D+GSK, respectively). GSK650394 (from day 0 to 6 postsurgery; 100 nM, 10 μL, i.t.) administration alleviates SNL-induced allodynia at days 3, 5, and 7 postsurgery in SNL animals.

研究領(lǐng)域
研究領(lǐng)域	Developmental BiologyEmbryogenesisEmbryonic stem cellsSurface molecules Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Stem CellsEmbryonic Stem CellsIntracellular Drug DiscoverySmall Molecule DrugLead Compound Discovery

GSK 650394 890842-28-1溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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GSK 650394 890842-28-1

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