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簡要描述：AG-337;Nolatrexed dihydrochloride 152946-68-4Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity.
產(chǎn)品型號：abs47028112廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-01-19訪 問 量：593產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 152946-68-4 |
|---|---|---|---|
| 分子式 | C14H14Cl2N4OS | 純度 | C14H14Cl2N4OS 分子量： 357.26 純度/級別： 98% |
| 分子量 | 357.26 | 貨號 | abs47028112 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | is the dihydrochloride salt of nolatrex | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
AG-337;Nolatrexed dihydrochloride 152946-68-4
| 產(chǎn)品描述 | |
| 描述 | Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | 鹽酸諾拉曲塞；二鹽酸諾拉曲塞 |
| 外觀 | Off-White to Pale Yellow Solid |
| 可溶性/溶解性 | DMSO > 10 mM |
| 參考文獻(xiàn) | |
| 參考文獻(xiàn) |
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| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | EpigeneticsDNA / RNADNA SynthesisOther MetabolismPathways and ProcessesMetabolic signaling pathwaysNucleotide metabolismPurine and pyrimidine synthesis Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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