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簡要描述：BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system.
產(chǎn)品型號(hào)：abs810013廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-10-30訪 問 量：2531產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 19542-67-7 |
|---|---|---|---|
| 分子式 | C10H9NO2S | 純度 | >98 % |
| 分子量 | 207.25 | 貨號(hào) | abs810013 |
| 規(guī)格 | 5mg;10mg;25mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | Also inhibiting components of the ubiqui | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 產(chǎn)品描述 | |
| 描述 | BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. Also inhibiting components of the ubiquitin system. |
| 純度 | >98 % |
| 儲(chǔ)存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | BAY11-7082；BAY117082 |
| 外觀 | White to off white solid |
| 可溶性/溶解性 | DMSO ：41 mg/mL (197.82 mM) Ethanol ：10 mg/mL (48.25 mM) |
| 生物活性 | |
| 靶點(diǎn) | E2-conjugating enzymes；IκBα phosphorylation |
| In vitro(體外研究) | Bay 11-7082, an inhibitor of NF-κB, induces apoptosis of HTLV-I-infected T-cell lines but only negligible apoptosis of HTLV-I-negative T cells. Bay 11-7082 rapidly and efficiently reduces the DNA binding of NF-κB in HTLV-I-infected T-cell lines and down-regulated the expression of the antiapoptotic gene, Bcl-xL, regulated by NF-κB. Bay 11-7082 selectively inhibits Tax-induced NF-κB activity in a human T-cell line. BAY 11-7082 inhibits NFκB signalling and is recently shown to inhibit the majority of E2 and E3 ligases tested by reacting covalently with the catalytic cysteine residues. Moreover, BAY 11-7082 also inhibits several tyrosine phosphatases by reacting with catalytic Cys residue of these enzymes. NSC 697923 is originally shown to inhibit the E2 ligase Ubc13-Uev1A. BAY 11-7082 inhibits the phosphorylation of IκBα and activation of NF-κB, induces the death of HBL-1 cells. BAY 11-7082 completely suppresses the LPS-stimulated and IL-1-stimulated phosphorylation of the activation loop of IKKβ. BAY 11-7082 acts by inhibiting TNF-α-induced phosphorylation of IκB-α, resulting in decreased NF-κB and decreases expression of adhesion molecules. |
| In vivo(體內(nèi)研究) | BAY 11-7082 (2.5 mg/kg and 5 mg/kg; intratumoral injection; twice-weekly for 21 days ) significantly suppresses tumor growth in a dose-dependent manner. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | CancerCell cycleCell cycle inhibitorsp53 pathway Cell CycleCell Cycle Inhibitorsp53 Proteolysis / UbiquitinProteasome / UbiquitinDeubiquitination EpigeneticsUbiquitin & Ubiquitin Like ModifiersDeubiquitination MicrobiologyInterspecies InteractionHost Virus Interaction Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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