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簡(jiǎn)要描述：β-Actin抗體，a ubiquitous eukaryotic protein, is the major component of the cytoskeleton.
產(chǎn)品型號(hào)：abs132001廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-10-23訪 問(wèn) 量：2630產(chǎn)品分類(lèi)
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | - |
|---|---|---|---|
| 分子式 | - | 純度 | 濃度：1mg/ml |
| 分子量 | Predicted molecular weight: 42kD Disclai | 貨號(hào) | abs132001 |
| 規(guī)格 | 50ug;100ug | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | WB 1:3000-1:20000, IHC 1:200, IF/ICC 1:1 | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
| 概述 | |
| 描述 | β-Actin抗體，Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton. At least six isoforms are known in mammals. Nonmuscle β- and γ-actin, also known as cytoplasmic actin, are predominantly expressed in nonmuscle cells, controlling cell structure and motility. |
| 別名 | β-Actin抗體;βActin |
| 宿主 | Rabbit |
| 特異性 | Beta actin antibody detects endogenous levels of total Beta actin. |
| 反應(yīng)種屬 | Human, Mouse, Rat, Pig, Zebrafish, Dog, Monkey, Fish |
| 預(yù)測(cè)反應(yīng)種屬 | Xenopus laevis, Chicken, Rabbit, Pig, Dog, Bovine, Sheep, Horse |
| 應(yīng)用 | WB: 1:3000-1:20000, IHC: 1:200, IF: 1:100-1:500, ICC: 1:100-1:500, ELISA(peptide): 1:20000-1:40000 |
| 分子量 | Predicted molecular weight: 42kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 | A synthesized peptide derived from human Beta actin. |
| 性能 | |
| 濃度 | 1mg/ml |
| 純化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin. |
| 類(lèi)型 | Polyclonal Antibody |
| 儲(chǔ)存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存儲(chǔ)溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
| 標(biāo)記 | Unlabeled |
| 修飾 | Unmodified |
| 靶標(biāo) | |
| 背景說(shuō)明 | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| 翻譯后修飾 | ISGylated.Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148). |
| 細(xì)胞定位 | Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane; |
| UniProt | P60709 |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Signal TransductionCytoskeleton / ECMCytoskeletonMicrofilamentsActin etcActin Tags & Cell MarkersSubcellular MarkersCytoskeletonActin |
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