Mouse anti-β-Actin Monoclonal Antibody

簡要描述：Mouse anti-β-Actin Monoclonal Antibody,It is one of six different actin proteins. Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton.

產(chǎn)品型號：abs132184
廠商性質(zhì)：生產(chǎn)廠家
更新時間：2025-10-31
訪問量：2297

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藥物陽性對照抗體磷酸化抗體二抗病毒抗體標簽抗體內(nèi)參抗體其它一抗

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品牌	absin	貨號	abs132184
規(guī)格	50ug;100ug	供貨周期	一周
主要用途	It is one of six different actin protei	應用領域	化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合

Mouse anti-β-Actin Monoclonal Antibody

概述
描述	Beta-actin (PS1TP5-binding protein 1), also known as ACTB, PS1TP5BP1. Entrez Protein NP_001092. It is one of six different actin proteins. Actin, a ubiquitous eukaryotic protein, is the major component of the cytoskeleton.Actins are highly conserved proteins that are involved in various types of cell motility, structure, and integrity. Actin is ubiquitously expressed in all eukaryotic cells. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.
別名	β-Actin抗體;βActin
宿主	Mouse
特異性	beta-Actin antibody detects endogenous levels of total beta-Actin.
反應種屬	Human, Mouse, Rat, Monkey, Hamster
應用	WB: 1:500-1:2000, ICC: 1:200-1:1000, FCM: 1:200-1:400, ELISA: 1:20000-1:40000
分子量	Predicted molecular weight: 43KD
免疫原	Purified recombinant fragment of human beta-Actin expressed in E. Coli.
性能
濃度	1mg/ml
純化方法	Affinity-chromatography.
類型	Monoclonal Antibody
儲存/保存方法	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存儲溶液	Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
使用方法	WB,IF/ICC,ELISA,FCM
靶標
背景說明	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
翻譯后修飾	ISGylated.Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.(Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
細胞定位	Cytoskeleton;Cytosol;Extracellular region or secreted;Nucleus;Plasma Membrane;
UniProt	P60709

Mouse anti-β-Actin Monoclonal Antibody溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究

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