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ELN 441958 913064-47-8 ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM.
PI3065 955977-50-1 PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR.
CDK4-IN-1 1256963-02-6 CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC5015 uM)
LY2409881 triHCl 946518-60-1 LY2409881 trihydrochloride is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.
LCL161 1005342-46-0 LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.
Fimepinostat 1339928-25-4 Fimepinostat potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes.
Pyrazolo[1,5-a]pyrimidine 4h 597544-21-3 Detail unknown.
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